Dr. Lily Houghton enlists the aid of wisecracking skipper Frank Wolff to take her down the Amazon in his dilapidated boat. Together, they search for an ancient tree that holds the power to heal – a discovery that will change the future of medicine.
Jason Kelly is one week away from marrying his boss's uber-controlling daughter, putting him on the fast track for a partnership at the law firm. However, when the straight-laced Jason is tricked into driving his foul-mouthed grandfather, Dick, to Daytona for spring break, his pending nuptials are suddenly in jeopardy. Between riotous frat parties, bar fights, and an epic night of karaoke, Dick is on a quest to live his life to the fullest and bring Jason along for the ride.
Hoping to bring his family closer together and to recreate his childhood vacation for his own kids, a grown up Rusty Griswold takes his wife and their two sons on a cross-country road trip to the coolest theme park in America, Walley World. Needless to say, things don't go quite as planned.