Picking up immediately after the events in Resident Evil: Retribution, Alice (Milla Jovovich) is the only survivor of what was meant to be humanity's final stand against the undead. Now, she must return to where the nightmare began - The Hive in Raccoon City, where the Umbrella Corporation is gathering its forces for a final strike against the only remaining survivors of the apocalypse.
In a world ravaged by a virus infection, turning its victims into the Undead, Alice continues on her journey to find survivors and lead them to safety. Her deadly battle with the Umbrella Corporation reaches new heights, but Alice gets some unexpected help from an old friend. A new lead that promises a safe haven from the Undead takes them to Los Angeles, but when they arrive the city is overrun by thousands of Undead - and Alice and her comrades are about to step into a deadly trap.
Years after the Racoon City catastrophe, survivors travel across the Nevada desert, hoping to make it to Alaska. Alice joins the caravan and their fight against hordes of zombies and the evil Umbrella Corp.
Two crew members wake up on an abandoned spacecraft with no idea who they are, how long they've been asleep, or what their mission is. The two soon discover they're actually not alone - and the reality of their situation is more horrifying than they could have imagined.
During a space voyage, four scientists are altered by cosmic rays: Reed Richards gains the ability to stretch his body; Sue Storm can become invisible; Johnny Storm controls fire; and Ben Grimm is turned into a super-strong … thing. Together, these "Fantastic Four" must now thwart the evil plans of Dr. Doom and save the world from certain destruction.