A scientist, Dr Holander, takes his niece Miranda to Mexico in an attempt to reverse the effects of the alien DNA he used to create her. However the treatment goes horribly wrong, and sets Miranda on a killing spree as she sets out to find a mate.
When the evil wizard Gargamel chases the tiny blue Smurfs out of their village, they tumble from their magical world and into ours -- in fact, smack dab in the middle of Central Park. Just three apples high and stuck in the Big Apple, the Smurfs must find a way to get back to their village before Gargamel tracks them down.