Oregon, 1851. Hermann Kermit Warm, a chemist and aspiring gold prospector, keeps a profitable secret that the Commodore wants to know, so he sends the Sisters brothers, two notorious assassins, to capture him on his way to California.
A university student and some classmates are recruited to carry out a private experiment -- to create a poltergeist. Their subject: an alluring, but dangerously disturbed young woman. Their quest: to explore the dark energy that her damaged psyche might manifest. As the experiment unravels along with their sanity, the rogue PHD students, led by their determined professor, are soon confronted with a terrifying reality: they have triggered an unspeakable force with a power beyond all explanation.