A bizarre accident lands Frank Harris in Cool World, a realm of cartoons. Years later, cartoonist Jack Deebs, who's been drawing Cool World, crosses over as well. He sets his lustful sights on animated femme fatale Holli Would, but she's got plans of her own to become real, and it's up to Frank to stop her.
Actress Reese Holden has been offered a small fortune by a book editor if she can secure for publication the love letters that her father, a reclusive novelist, wrote to her mother, who has since passed away. Returning to Michigan, Reese finds that an ex-grad student and a would-be musician have moved in with her father, who cares more about his new friends than he does about his own health and well-being.