After another deadly shark attack, Ellen Brody decides she has had enough of New England's Amity Island and moves to the Caribbean to join her son, Michael, and his family. But a great white shark has followed her there, hungry for more lives.
After failing to kill stubborn survivor Laurie and taking a bullet or six from former psychiatrist Dr. Sam Loomis, Michael Myers has followed Laurie to the Haddonfield Memorial Hospital, where she's been admitted for Myers' attempt on her life. The institution proves to be particularly suited to serial killers, however, as Myers cuts, stabs and slashes his way through hospital staff to reach his favorite victim.