A listless Wade Wilson toils away in civilian life with his days as the morally flexible mercenary, Deadpool, behind him. But when his homeworld faces an existential threat, Wade must reluctantly suit-up again with an even more reluctant Wolverine.
To test its top-secret Human Hibernation Project, the Pentagon picks the most average Americans it can find - an Army private and a prostitute - and sends them to the year 2505 after a series of freak events. But when they arrive, they find a civilization so dumbed-down that they're the smartest people around.
Wisecracking mercenary Deadpool battles the evil and powerful Cable and other bad guys to save a boy's life.