Two decades after surviving a massacre on October 31, 1978, former baby sitter Laurie Strode finds herself hunted by persistent knife-wielder Michael Myers. Laurie now lives in Northern California under an assumed name, where she works as the headmistress of a private school. But it's not far enough to escape Myers, who soon discovers her whereabouts. As Halloween descends upon Laurie's peaceful community, a feeling of dread weighs upon her -- with good reason.
In the year 2035, convict James Cole reluctantly volunteers to be sent back in time to discover the origin of a deadly virus that wiped out nearly all of the earth's population and forced the survivors into underground communities. But when Cole is mistakenly sent to 1990 instead of 1996, he's arrested and locked up in a mental hospital. There he meets psychiatrist Dr. Kathryn Railly, and patient Jeffrey Goines, the son of a famous virus expert, who may hold the key to the mysterious rogue group, the Army of the 12 Monkeys, thought to be responsible for unleashing the killer disease.
The near future, a time when both hope and hardships drive humanity to look to the stars and beyond. While a mysterious phenomenon menaces to destroy life on planet Earth, astronaut Roy McBride undertakes a mission across the immensity of space and its many perils to uncover the truth about a lost expedition that decades before boldly faced emptiness and silence in search of the unknown.