Forensic psychologist Alex Cross travels to North Carolina and teams with escaped kidnap victim Kate McTiernan to hunt down "Casanova," a serial killer who abducts strong-willed women and forces them to submit to his demands. The trail leads to Los Angeles, where the duo discovers that the psychopath may not be working alone.
Jordan Turner (Halle Berry) is an experienced 911 operator but when she makes an error in judgment and a call ends badly, Jordan is rattled and unsure if she can continue. But then teenager Casey Welson (Abigail Breslin) is abducted in the back of a man's car and calls 911. And Jordan is the one called upon to use all of her experience, insights and quick thinking to help Casey escape, and not just to save Casey, but to make sure the man is brought to justice.