Hard-to-crack ex-CIA man, Jack Byrnes and his wife, Dina head for the warmer climes of Florida to meet son-in-law-to-be, Greg Focker's parents. Unlike their happily matched offspring, the future in-laws find themselves in a situation of opposites that definitely do not attract.
Rising executive Tim Conrad works for a boss who hosts a monthly dinner in which the guest who brings the biggest buffoon gets a career-boost. Tim plans on not attending until he meets Barry, a man who builds dioramas using stuffed mice. Barry's blundering but good intentions send Tim's life into a downward spiral, threatening a major business deal and possibly scuttling Tim's engagement to his fiancee.
It has taken 10 years, two little Fockers with wife Pam and countless hurdles for Greg to finally get in with his tightly wound father-in-law, Jack. After the cash-strapped dad takes a job moonlighting for a drug company, Jack's suspicions about his favorite male nurse come roaring back. When Greg and Pam's entire clan descends for the twins' birthday party, Greg must prove to the skeptical Jack that he's fully capable as the man of the house.