The inhabitants of the British Isles have lost their battle against the onslaught of disease, as the deadly rage virus has killed every citizen there. Six months later, a group of Americans dare to set foot on the isles, convinced the danger has come and gone. But it soon becomes all too clear that the scourge continues to live, waiting to pounce on its next victims.
Rob "Fish" Fishman is the drummer in '80s hair metal band Vesuvius. He's unceremoniously booted as the group signs a big record deal, is out of the music world for 20 years - and then receives a second chance with his nephew's band.
Nerdy teenager Denis Cooverman (Paul Rust) harbors a secret crush on Beth Cooper (Hayden Panettiere), the hottest girl in high school. During his graduation speech, Denis lets the cat out of the bag and declares his love for Beth, who, instead of dissing Denis, shows up at his house later that day and promises to show him the time of his life.
When New Orleans cop Danny Fisher prevents a brilliant thief from successfully carrying out his latest heist, the thief's girlfriend is accidentally killed. Hungry for revenge, the criminal mastermind breaks out of prison and kidnaps Danny's fiancee. To save her, Danny must successfully navigate his way through an elaborate series of tasks and puzzles, or else watch the love of his life die.